Many workers have supported the theory of a possibility of two powers, growth inhibiting and promoting factors, being in a state of equilibrium in normal tissue. In 1933 Spemann´) advanced his hypothesis that a tumor can be formed when the above two factors are unbalanced. In 1962 Paul, ^(14)) on the other hand, reported that when cancer forms there must be a resulting unbalance in the homeostatic mechanism of the human body´s cell.
Since 1958, Chin´s^(19)) extraction of factors which sharply inhibit the growth of Ehrlich ascites cancer and N-F sarcoma in normal rat liver. Many workers have been able to successfully extract both growth inhibiting and promoting substances of tissue from various animals and human organs such as animal liver, spleen, kidney, human plasma, lung, heart, muscle, bone marrow, periosteum, human placenta and various body fluids. In order to pursue further whether the brain tissue of various animals contains the above tissue factors and different physiologic metabolism or not, the author has examined phenomena about how the extracted substance might have influenced Ehrlich cancer and N-F sarcoma, by applying the procedure of the extracting brain tissue factors from dogs, cows and rats.
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